Neurobiology of Disease CSF Biomarkers in Prediction of Cerebral and Clinical Change in Mild Cognitive Impairment and Alzheimer’s Disease

نویسندگان

  • Anders M. Fjell
  • Kristine B. Walhovd
  • Christine Fennema-Notestine
  • Linda K. McEvoy
  • Donald J. Hagler
  • Dominic Holland
  • James B. Brewer
چکیده

Anders M. Fjell,1,2 Kristine B. Walhovd,1,2 Christine Fennema-Notestine,3,4 Linda K. McEvoy,4 Donald J. Hagler,4 Dominic Holland,4 James B. Brewer,4,5 and Anders M. Dale,3,4 for the Alzheimer’s Disease Neuroimaging Initiative 1Center for the Study of Human Cognition, Department of Psychology, University of Oslo, NO-0317 Oslo, Norway, 2Department of Neuropsychology, Ullevaal University Hospital, NO-0407 Oslo, Norway, and Departments of 3Radiology, 4Psychiatry, and 5Neuroscience, University of California, San Diego, La Jolla, California 92093

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P 62: Markers of Neuroinflammation Related to Alzheimer\'s Disease Pathology in the Elderly

Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. In vitro and animal studies have linked neuroinflammation to Alzheimer's disease (AD) pathology. Studies on marke...

متن کامل

The most valuable biomarkers of Alzheimer\'s disease: a review article

Alzheimer’s disease (AD) is the most popular type of dementia in elderly and is described by a progressive loss of cognitive capacity and severe neurodegeneration which typically begins with memory deficits. The major biomarkers of AD include total tau, phosphorylated-tau and 42 amino acid isoform of amyloid beta that reflect neurodegeneration and indicate the pathophysiological processes in AD...

متن کامل

A survey on Alzheimer’s disease detection using gait analysis

Introduction: Early detection of Alzheimer's disease (AD), as a neurodegenerative disease and the most common cause of dementia in the elderly people, using gait analysis have been particularly noted by researcher in recent years. Because this novel method is non-invasive, less cost, and feasible in non-clinical and laboratory environments. Therefore, in this Meta-Analysis review article, detec...

متن کامل

Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification.

Magnetic resonance imaging (MRI) patterns were examined together with cerebrospinal fluid (CSF) biomarkers in serial scans of Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with mild cognitive impairment (MCI). The SPARE-AD score, summarizing brain atrophy patterns, was tested as a predictor of short-term conversion to Alzheimer's disease (AD). MCI individuals that converted to...

متن کامل

Identification of mild cognitive impairment disease using brain functional connectivity and graph analysis in fMRI data

Background: Early diagnosis of patients in the early stages of Alzheimer's, known as mild cognitive impairment, is of great importance in the treatment of this disease. If a patient can be diagnosed at this stage, it is possible to treat or delay Alzheimer's disease. Resting-state functional magnetic resonance imaging (fMRI) is very common in the process of diagnosing Alzheimer's disease. In th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010